Abstract Search

ea0009oc8 | Oral Communication 1: Diabetes and metabolism | BES2005

Blockade of the Neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous Peptide YY (3-36) on food intake

Abbott C , Small C , Kennedy A , Neary N , Sajedi A , Ghatei M , Bloom S

The gastrointestinal-derived hormone peptide YY (PYY) is released from intestinal L-cells post-prandially in proportion to calorie intake, and modulates food intake. Peripheral administration of PYY (3-36) reduces food intake and body weight in rodents and suppresses appetite and food intake in humans. PYY(3-36) is hypothesised to inhibit food intake via activation of the auto-inhibitory pre-synaptic neuropeptide Y (NPY) Y2 receptor (Y2R) present on arcua...

0 shares

ea0009oc24 | Oral Communication 3: Neuroendocrinology | BES2005

Feeding effects of the gut hormones ghrelin, peptide YY3-36 and oxyntomodulin in lean and obese mice

Druce M , Neary N , Small C , Monteiro M , Thompson E , Ghatei M , Bloom S

The gastric hormone ghrelin stimulates feeding whereas the intestinal hormones peptide YY3-36 (PYY3-36) and oxyntomodulin inhibit feeding. In order to determine whether these gut hormones retain their effects in obesity, they were administered in vivo intraperitoneally to unanaesthetised lean and obese mice. Forty eight C57Bl/6 male mice were randomised to receive either low-fat diet (4.5% fat) or high fat diet (60% fat). After 16 weeks, mice fed o...

0 shares

Endocrine Abstracts

Blockade of the Neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous Peptide YY (3-36) on food intake

Feeding effects of the gut hormones ghrelin, peptide YY3-36 and oxyntomodulin in lean and obese mice

BiosciAbstracts